عنوان مقاله:

نویسندگان:

سید محمد ابراهیم کامرانی، دکتر فرزین هادیزاده

Background: Cancer is one of leading cause of death in 21st century. There are several ways toward cancer treatment, like immunotherapy, radiotherapy, and chemotherapy. One of the main causes of treatment failure is multiple drug resistance. Several mechanisms are claimed for drug resistance, like change in metabolic pathways, overexpression of ABCtransporters and etc. Method: In this study we used microarray data that compared drug resistant cells with sensitive one to find differentially expressed genes (DEGs). Then by SRTRING software we analyzed protein-protein interactions. And then based on network parameter, we chose 10 hub gene to find their pathway in KEGG database. Finally, by Venn diagram we found common genes in down-regulated and up-regulated genes they have a high therapeutic value. Result: ABCB1 that is one of important transporters in MDR mechanism is in interaction with FN1, MMP-2, KDR, and SLC families. P3H2, RPH3AL, NCF1, NCF2 is common upregulated genes in three databases.

PPI-network analysis, multiple drug resistance, differentially expressed genes (DEG)

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محمد ابراهیم کامرانی، سید، فرزین هادیزاده، دکتر، 1404، مطالعه شبکه ای بیولوژی در مورد مقاومت چندگانه سرطان، کنگره بین المللی زیست پزشکی سرطان و سلولهای بنیادی، http://conf.sums.ac.ir/fa/archive_index.php?c=HN-icsbc1&aid=1514174