1- CAR T Cells در ایمونوتراپی سرطان: شمشیر دولبه پیشرفت‌ ها و چالش‌ ها

Background: Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a transformative approach in cancer treatment, showing significant efficacy in hematologic cancers. However, its application in solid tumors is limited due to challenges such as the tumor microenvironment and antigen heterogeneity. This review aims to highlight the efficacy, safety, and challenges of CAR و...

2- Pancreatic Cancer Diagnosis Using Different Machine Learning Algorithms

Pancreatic cancer has emerged as one of the most challenging and deadliest malignancies, due to a lack of exact and early diagnosis. With the advancement of technology and data science and the entry of artificial intelligence into the cancer research, many methods have been used in the early diagnosis of pancreatic cancer. The aim of this research is to identify the best machin و...

3- آنالیز خوشه ها و شبکه ارتباط پروتئین-پروتئین در مالتیپل میلوما

Background: Multiple Myeloma (MM) the neoplasm of bone marrow plasma cells constitutes approximately 10% of haematological malignancies worldwide and is the second most prevalent haematological cancer in developed countries. Despite the extended 5-year survival rates due to the recent advances in the treatment of this disease, patients still die mostly from their disease or tr و...

4- BAMLET (آلفا لاکتالبومین گاوی ساخته شده برای سلول‌های تومور کشنده) سلول‌های سرطان کولورکتال جهش یافته با RAS را از طریق مهار شار اتوفاژی با هدف قرار دادن کازئین کیناز یک آلفا ( CK1α) می‌کشد: گامی به سوی پزشکی شخصی

Background & aims: Mutation in RAS protein is one of the most common genetic changes in colorectal cancer cases. Oncogenic RAS mutations are usually dependent on the autophagy mechanism to maintain tumorigenesis. Additionally, it has been reported that casein kinase 1 alpha (CK1α) prevents aberrant activation of autophagy flux in RAS-mutated colorectal cancer cells. Given that و...

5- Safety and Feasibility of Theranostic Application of Tc99m/Lu177-PSMA in the Glioblastoma

Introduction Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an annual incidence of about 3 per 100,000 people in the United States. GBM has a poor prognosis, with a median survival time of 8–15 months for newly diagnosed patients and 3–9 months for those with recurrent disease. Despite the intensive standard treatment of surgery, radiation, و...

6- رونمایی از مسیرهای پیام رسانی کلیدی و تغییرات ژنومی در سرطان تیروئید

Background: Thyroid cancer (TC), one of the most common endocrine malignancies, is driven by various genetic alterations that influence key signaling pathways, leading to tumor initiation, progression, and metastasis. The RAS-BRAF-RET-MAPK- Wnt-β-Catenin signaling cascade plays a pivotal role. Methods: This review was conducted by searching peer-reviewed literature on key sign و...

7- کشف کاندید های بیومارکری سرطان مثانه: ترکیب توالی یابی حجیم RNA و داده های ریزآرایه

Background: Bladder cancer (BC) is the most common malignancy of the urinary system, causing about 200,000 deaths annually worldwide. Currently, cystoscopy is the best method for BC diagnosis. Only a limited number of markers are used for BC diagnosis and monitoring of disease progression. This study aims to discover new biomarkers for BC using bioinformatics tools. Method: F و...

8- َشناسایی تومور مغزی با ترکیب روش CNN و KFCM

Brain tumors pose significant health risks and require advanced diagnostic techniques for early detection. Traditional methods often fall short in accuracy and efficiency, necessitating the exploration of novel approaches. This paper proposes a combined method using Kernel-based Fuzzy C-means (KFCM) and Convolutional Neural Networks (CNN) for improved tumor identification. و...

9- The Effect of Aqueous Extract of Cistanche tubulosa on Stimulating Ovarian Tissue Stem Cells in a Mouse Model of POF

Background: Premature ovarian failure (POF) is a significant reproductive disorder affecting women under 40, characterized by the cessation of ovarian follicle development. Given the presence of stem cells in ovarian tissue, reactivating these cells may help restore ovarian function. The Oct4 gene is a crucial regulator of embryonic stem cell proliferation and may influence oog و...

10- Zika virus is a bridge to the future for the treatment of brain cancer cells

Glioblastoma multiforme is the most common malignant brain cancer, with more than 300,000 patients diagnosed with the disease worldwide every year. Mainly due to the high incidence of tumor recurrence and limited treatment options, the survival rate for such patients is weak (about 15 months). For such patients, oncolytic virotherapy-or the use of engineered viruses to infect و...

11- Effect of nursing intervention on improve quality of life in cancer patients undergoing radiotherapy and chemotherapy: A systematic review and meta-analysis

Abstract Background: Cancer patients who undergo radiotherapy and chemotherapy usually experience a low quality of life, improving their quality of life is very important so that they have the best lifestyle during the survival period. the aim of present systematic review and meta-analysis was to evaluate Effect of nursing intervention on improve quality of life in cancer pat و...

12- سنتز و کاهش سمیت متوتروکسات برای کاربردهای درمان سرطان

Methotrexate (MTX) is one of the drugs used to treat various types of cancer and autoimmune diseases, which acts as a folic acid antagonist. MTX works by inhibiting the enzyme dihydrofolate reductase, which disrupts DNA and RNA synthesis and slows cellular replication. Contrary to its medicinal effect, MTX has high toxicity, which can be reduced by using conjugation with differ و...

13- WGCNA-Based Analysis of Gene Expression in Normal and Hepatectomy Liver Tissues: Clinical Implications for Tumor Stage and Gender

Background: Liver diseases, particularly hepatocellular carcinoma (HCC), represent a major global health burden due to their high incidence and mortality rates. Total hepatectomy followed by liver transplantation remains the primary curative treatment for patients with end-stage liver disease and early-stage HCC. However, these procedures carry significant risks, including g و...

14- هوش مصنوعی در تشخیص و درمان سرطان

استفاده از هوش مصنوعی در تشخیص سرطان سینه در مراحل اولیه و درمان دقیق و موثر ان با استفاده از انالیز عکس های سینه و استخراج اطلاعات ان با استفاده از هوش مصنوعی باعث کاهش مرگ و میر این بیماری میشود و...

15- مطالعه شبکه ای بیولوژی در مورد مقاومت چندگانه سرطان

Background: Cancer is one of leading cause of death in 21st century. There are several ways toward cancer treatment, like immunotherapy, radiotherapy, and chemotherapy. One of the main causes of treatment failure is multiple drug resistance. Several mechanisms are claimed for drug resistance, like change in metabolic pathways, overexpression of ABCtransporters and etc. Method و...

16- بررسی اثرات ضد سرطانی نانوحامل هیبریدی نیوزوم-کادمیوم حاوی الیگودئوکسی نوکلئوتیدهای تله Sox2 تحت اعمال اشعه ایکس بر روی سلول های سه گانه منفی سرطان پستان

Introduction: Sox2 is one of the important oncoproteins in breast cancer. Sox2 plays a role in the proliferation, invasion, differentiation, recurrence and drug resistance of cancer cells. Cadmium (Cd) is a carcinogenic metal that has been shown by epidemiological studies to play an important role in the development of breast cancer. Niosomes (non-ionic surfactant vesicles) are و...

17- RNA های غیرکدکننده اگزوزومی در سرطان ریه

Exosomal non-codingRNA in Lung Cancer Faezeh Ziyaei1,2*, Mehrdad Hashemi1,2* 1- Department of Genetics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2- Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran • faeze.zi79@gmail.com , drmehashemi@gmail.com Cancer is ba و...

18- آنالیز بیوانفورماتیکی ATG7: یک ژن کلیدی در اتوفاژی سرطان مثانه

Background: Bladder cancer (BC) is one of the most prevalent malignancies of the urinary tract, often presenting as a highly heterogeneous disease with variable outcomes. Its management and prognosis depend heavily on early detection and understanding of the underlying molecular mechanisms driving tumor progression. Autophagy, a cellular process responsible for degrading and re و...

19- بررسی اثر محافظتی گیاه گل برنجاس بر التهاب روده ای ایجاد شده توسط داروی شیمی درمانی 5-فلوئورواوراسیل

Background: This study investigated the impact of the Millefolium Achillea on the intestinal mucositis induced by Fluorouracil (5-FU) in rats. Fluorouracil (5-FU) used as a chemotherapy drug for treatment of various cancers. patients undergoing 5-FU therapy suffer from a range of symptoms, including mucositis and diarrhea. Materials and Methods: The study groups included the و...

20- مبنای مولکولی اثربخشی ضدسرطانی مهارکننده‌های SGLT2

The anti-cancer efficacy of SGLT2 inhibitors is supported by a multifaceted molecular basis involving inhibition of glucose uptake, induction of apoptotic processes, modulation of critical survival pathways, and systemic metabolic alterations. As research progresses, these agents hold promise not only as diabetic medications but also as potential therapeutic options in oncology و...

21- مطالعات برهمکنش تجربی و نظری کمپلکس شیف ​​باز مس (II) با آلبومین سرم انسانی (HSA) و خواص ضد سرطانی

BRAGG intensities were calculated deploying Cu Kα and Mo Kα radiations at λ = 1.54184 Å and λ = 0.71073 Å, respectively, by the temperature of 140 K, operating a Rigaku SuperNova dual system diffractometer supplied by an Atlas CCD detector. The dataset processing was conducted and tuned for absorption by applying CrysAlisPro, firmly enclosing the crystals with a set of faces. S و...

22- کاهش تنظیم پروتئین های HDAC1، DNMT1 و MeCP2 در تنظیم بیان ژن گیرنده استروژن α در رده سلولی سرطان پستان MDA-MB 468 توسط siRNA

Down regulation of HDAC1, DNMT1 and MeCP2 proteins involved in regulation of estrogen receptor α gene expression in MDA-MB 468 breast cancer cell line by siRNA Zahra Hassanzadeh1, Fatemeh Hassanzadeh1, Rita Arabsolghar1,2 * 1 Department of Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran 2 Diagnostic Laboratory Sci و...

23- Artificial Intelligence Applications in Cancer Immunotherapy: A Comprehensive Review

Background: Artificial intelligence (AI) has emerged as a transformative force in cancer immunotherapy, enabling machines to perform complex medical tasks with minimal human intervention. The technology has demonstrated remarkable potential in revolutionizing healthcare systems, particularly in immunotherapy response prediction, diagnostic accuracy enhancement, and treatment o و...

24- شناسایی ژن های هاب کلیدی در سلول های بنیادی سرطان پستان: دستیابی به استراتژی های جدید در مقاومت در برابر درمان

Background: Breast cancer remains one of the most prevalent and deadly cancers among women worldwide. One of the major challenges in treating breast cancer is the presence of cancer stem cells (CSCs), which are responsible for initiating metastasis and treatment resistance. Also, CSCs often lead to relapse even after an initially successful response to therapy. Therefore, targe و...

25- ترنسفورمرهای تفسیر پذیر در بیوانفورماتیک: رویکردی جدید برای تجزیه و تحلیل قابل تفسیر بیان ژن و تعامل های پروتئین-پروتئین در سلول های بنیادی

Explainable Transformers in Bioinformatics: A Novel Approach for Interpretable Analysis of Gene Expression and Protein-Protein Interactions in Stem Cells Naeimeh M. Karimi1, Mehdi Rezaeian2,*, Meysam Mobasheri3 1 Department of Computer Engineering, Yazd University, Yazd, Iran 2 Department of Computer Engineering, Yazd University, Yazd, Iran 3 International Institute of New و...

26- تشخیص مقاومت دارویی در سلول های تومور مغزی در کشت های 2 بعدی، 3 بعدی با استفاده از کیت کموبیوگرام

The chemogram kit is an innovative method used in oncology to optimize the selection of chemotherapy drugs for cancer patients.Oncologists extract a sample from the patient's tumor. After tumor cells are cultured in the laboratory, the cells are exposed to a diverse panel of chemotherapy drugs. By evaluating the response of tumor cells to different drugs, specialists can i و...

27- سطح بیان محصولات GOT1 و درمان سرطان در LGG (درجه گلیوما پایین)

Expression level of GOT1 products and treatment of the cancer in LGG( lower glioma grade) Hamidreza Roshani Dastgerdi, Aida sattari, Pardis Karimian, Aysa Nasiri, Mohammad Rezaei, Mansoureh Azadeh 1-Zist Fanavari Novin Biotechnology Institute, Isfahan, Iran Corresponding author E-mail: ma.azadeh1382@gmail.com Background: Glioma, a primary brain or spi و...

28- هیدروژل قابل تزریق حساس به دمای F127 دارای اثر دوگانه در دارورسانی هدفمند برای درمان تومور

ABSTRACT: The purpose of this study was to design a dual effect injectable hydrogel, with temperature-sensitive property for localized magnetic hyperthermia and drug delivery, simultaneously. Magnetic hydrogel solution was injected peritumoral, and it automatically gelled after warming up to body temperature. This system was achieved by dispersing γ-Fe2O3 magnetic nanoparticle و...

29- اثرات رسوراترول، اسید گالیک و پیپرین در بیان miR-17، miR-92b، miR-181a، miR-222، BAX، BCL-2، MCL-1، WT1، c-Kit، و CEBPA در انسان حاد سلول های لوسمی میلوئید و نقش آنها در آپوپتوز

MicroRNAs (miRs) play a crucial role in the leukemogenesis and the prognosis of acute myeloid leukemia (AML). This study investigated the therapeutic effects of resveratrol, gallic acid, and piperine as natural anticancer agents on the HL-60 cell line and their roles in apoptosis. In this experimental study, quantitative analysis of miRs, including miR-17, miR-92b, miR-181a و...

30- گفتگوی متقابل بین miR-146a و TNF-α در مسیر سیگنالینگ NF-kB در پاتوژنز سرطان پستان DCIS و LCIS

The NF-kappa B (NF-κB) signaling pathway can help to explain the link between inflammation and cancer. Tumor necrosis factor-alpha (TNF-α) has been shown to promote tumor initiation, promotion, as well as invasion and metastasis as necessary tissue architecture for tumor development through activation of NF-κB. MiR-146a influences the function of NF-κB and contributes to differ و...

31- ژن های مشترک بین سرطان های سینه و تخمدان عمدتا مسیرهای چرخه سلولی و میتوز را کنترل می نمایند

سرطان سینه یک بدخیمی شایع با نرخ مرگ و میر قابل توجهی در بین زنان است. بر اساس داده های آماری سال 2022، سرطان سینه منجر به مرگ حدود 670000 نفر در سراسر جهان شده است. همچنین، سرطان تخمدان به عنوان هفتمین بدخیمی شایع و هشتمین علت مرگ و میر ناشی از سرطان در میان زنان شناخته شده است. مطالعات نشان داده که شباهت هایی بین سرطان سینه و تخمدان، به ویژه در مورد عوامل هورمونی و جهش های مش و...

32- مطالعه فازI بررسی تزریق اینتراتکال سلول‌های کشنده طبیعی آلوژنیک در کودکان مبتلا به گلیوم‌های مغزی

Introduction: pediatric brain tumors is a life-threating challenge with poor prognosis. Here, we report a phase I study of repeated doses of intrathecal infusions of natural killer (NK) cells in pediatric patients with recurrent and resistant treatment of high-grade glioma. Methods: Nine patients underwent NK cell therapy, receiving 5×107 NK cells/infusion up to 10 episodes. و...

33- پروبیوتیک ها: مزایای بالقوه و ایمنی در بدخیمی های خونی

Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, p و...

34- Identification of pathways contributing to progress of glioblastoma multiform using gene expression and gene set enrichment analysis

Background: Glioblastoma multiform is a type of brain cancer characterized by rapid progression and low survival rates. The aim of this research is to identify hub genes and understand their interactions to uncover cellular pathways that contribute to tumor progression. Method: Data was obtained from the GEO database consisting of 8 tumor and 8 normal samples. Analysis was per و...

35- اپلیکیشن جامع مدیریت سلامت مبتنی بر هوش مصنوعی برای بیماران سرطانی تحت شیمی درمانی: کمویار

Background: Chemotherapy, a common cancer treatment, often leads to challenging side effects, such as nausea, fatigue, and neuropathy, which impact patients' physical and mental well-being. Despite regular checkups, there is a lack of continuous, personalized monitoring, causing delayed interventions and reduced quality of life. An AI-driven solution is needed for real-tim و...

36- تحلیل بیوانفورماتیک یکپارچه بر پروفایل‌های بیان ژن در نمونه‌های جهش‌یافته idh1 عاملی برای بروز low grade گلیوما

Background: Gliomas are the most common primary brain tumors, noted for their heterogeneity and aggressive nature. Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are frequently associated with better prognosis and lower-grade gliomas. Understanding the molecular differences between IDH1 mutant and wild-type gliomas is essential for developing targeted therapies and imp و...

37- Artificial Intelligence in Cancer Diagnosis and Management

The need for novel diagnostic and therapeutic approaches is highlighted by the increasing prevalence of cancers, particularly breast, prostate, skin, lung, and colon cancers. Although early detection plays a crucial role in improving patient outcomes; however, many cancers are diagnosed at advanced stages, leading to high mortality. Applications of artificial intelligence (AI) و...

38- Integration of Artificial Intelligence and Advanced Imaging A New Era in Precision Radiotherapy

Background: The integration of artificial intelligence (AI) with advanced imaging technologies represents a significant paradigm shift in precision radiotherapy. Recent developments in deep learning algorithms and computational power have enabled unprecedented accuracy in treatment planning and delivery. While traditional radiotherapy relies heavily on manual interpretation, t و...

39- سرکوب پیشرفت تومور تخمدان از طریق هدف گیری تومور با siRNA-COG3 و مهار متاستاز و رگزایی در محیط کشت سلولی و موش

Abstract: Background: The COG complex is implicated in the tethering of retrograde intra-Golgi vesicles, which involves vesicular tethering and SNAREs. SNARE complexes mediate the invasion and metastasis of cancer cells through MMPs which activate growth factors for ECM fragments by binding to integrin receptors. Increasing MMPs is in line with YKL40 since YKL40 is linked to و...

40- عملکرد نوتروفیل در ریزمحیط تومور و ارتباط آن با پیش آگهی تومور

Abstract Background: One of the major roles of the immune system is the recognition and elimination of malignant cells. Neutrophils are the most abundant type of white blood cells and play a complex role in the tumor microenvironment. They were initially recognized for their function in acute inflammation and pathogen defense. Neutrophils are now understood to be key participa و...

41- میکروسیال های اینرسی برای تشخیص و درمان سرطان

پیشرفت‌ها در دستگاه‌های میکروسیال تأثیر قابل‌توجهی بر زمینه‌های زیست پزشکی، به‌ویژه تحقیقات سرطان داشته است. به طور کلی سیستم های میکروسیال به دو نوع فعال و غیرفعال تقسیم می شوند. سیستم‌های فعال از نیروهای خارجی برای دستکاری ذرات استفاده می‌کنند، در حالی که سیستم‌های غیرفعال به دینامیک سیالات درونی متکی هستند. دستگاه‌های میکروسیال اینرسی، شاخه‌ای از میکروسیال‌های غیرفعال، از جر و...

42- استراتژی های درمانی برای عوارض جانبی قلبی عروقی مهارکننده های تیروزین کیناز BCR-ABL

Background: BCR-ABL tyrosine kinase inhibitors, such as Imatinib, Dasatinib, and Nilotinib, have significantly improved the management of chronic myeloid leukemia, but they are associated with various cardiovascular adverse events including hypertension, heart failure, and thromboembolic events, which directly related to patient’s quality of life and morbidity. Thus, understan و...

43- بررسی تعاملات TP53 و HER2 در سرطان پستان: از جهش ژنتیکی تا مقاومت درمانی  

Breast cancer is a multifaceted disease, characterized by the uncontrolled growth and division of breast cells. This abnormal cell behavior can arise from various genetic, environmental, and hormonal factors, making each case unique and difficult to predict The tumor suppressor p53 was initially found in 1979 and has been recognized for its substantial association with HER2 in و...

44- محور میکروبیوم-سیستم ایمنی: بازیگر کلیدی در سلامت و بیماری انسان

Background: The dynamic interaction between the human microbiome and the immune system is discussed, which finally dictates health and disease. A complex of bacteria, fungi, viruses, and parasites makes up the microbiome, which substantially modulates immune responses, while the immune system acts back on the structure and function of the microbiome. Many disorders related to t و...

45- اثربخشی و ایمنی ترکیبات مهارکننده نقاط وارسی ایمنی در بیماران مبتلا به سرطان ریه سلول غیر کوچک در دوره پیرامون جراحی

Efficacy and Safety of Immune Checkpoint Inhibitor Combinations in Perioperative Patients with Non-Small Cell Lung Cancer Mohadese Mohamadzade1,2, Faezeh Ziyaei3,4, Mehrnegar Moobed5, Farimah Foroughi Biuki5, Nooshin Barikrow6* 1 Department of Microbiology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. 2 D و...

46- استفاده از میکروبیوم برای تشخیص زودهنگام سرطان کولون بر پایه یادگیری ماشین

Cancer is one of the deadliest diseases human society has faced throughout history of medicine and health care provisions and of the leading cause of cancer-related deaths and disability annually throughout the entire world according to WHO reports on global burden of diseases. Colorectal cancer as one of the most common cancers and the second cause of cancer deaths worldwide. و...

47- بررسی بیان ژن آلفا-N-استیل گالاکتوزامینیداز و ارتباط آن با مهاجرت و متاستاز در رده های سلولی سرطانی

Background: Alpha-N-acetylgalactosaminidase, commonly known as Nagalase, is an enzyme encoded by the NAGA gene, highly expressed in liver cells. Nagalase breaks down specific sugar chains on sphingolipids and glycoproteins, contributing to lysosomal storage. Elevated levels of Nagalase are frequently observed in cancer patients, though there is no structural difference between و...

48- مهارکننده‌های ایمون چک پوینت ها و عارضه جانبی میوکاردیت مقاوم به کورتیکواستروئید: مروری بر گزینه‌های درمانی

Immune Checkpoint Inhibitors (ICIs) can lead to a range of cardiovascular side effects (cvAEs), such as myocarditis, arrhythmias, and non-inflammatory left ventricular dysfunction (NILVD). Myocarditis is particularly alarming due to its potential severity and quick onset, often arising within the first six weeks of treatment. The standard initial approach for treating myocardit و...

49- Advancements in Exosome-Mediated Drug Delivery Systems for Colorectal, Breast, and Lung Cancer Treatment

Background The use of exosomes for targeted drug delivery has attracted significant interest as a potential solution to address the limitations of conventional cancer treatments, such as chemotherapy and radiation therapy. Colorectal cancer (CRC), breast cancer, and lung cancer are among the most common and aggressive cancers globally. Despite significant advances in cancer th و...

50- اهمیت و روش های تصویربرداری از مسیر سیگنال دهی cGAS_STING در ایمونوتراپی تومورهای سرطانی

The cGAS_STING pathway is a vital pathway in the immune system that impacts nearly all aspects of tumorigenesis and defens against viruses especially viruses that lead to cancer such as:HPV,HBV,HCV,EBV,HTLV_1,KSHV.In this pathway,after the recognition of DNA and its activation,it leads to the accumulation and activation of cGAMP.Then the activation of kinases occurs,which subse و...

51- متفورمین بیان انکوژنیک ژن HOTAIR را از طریق متیلاسیون پروموتر تعدیل می کند و انتقال اپیتلیال - مزانشیمی را در سلول های MDA-MB-231 معکوس می کند.

Epithelial-mesenchymal transition (EMT) is a biological event, which critically regulates migration and invasion of cancer cells. EMT is regulated by several protein and nonprotein factors (such as noncoding RNAs). HOTAIR is an oncogenic long noncoding RNA that stimulates EMT in cancers. In the current study, we investigated the effect of metformin on EMT behavior and HOTAIR e و...

52- مکانیسم‌های مولکولی مقاومت دارویی در سلول‌های بنیادی سرطانی: هدف‌گیری مسیرهای سیگنالینگ برای افزایش کارایی درمان سرطان

ABSTRACT This review delves into the molecular mechanisms underlying drug resistance in cancer stem cells (CSCs) and the pivotal role of signaling pathways in this process. CSCs, with their unique characteristics such as self-renewal, long-term survival, and resistance to standard therapies, pose significant challenges in cancer treatment and are a major factor in tumor recurr و...

53- بررسی تاثیر C-Phycocyanin بر بیان ژن های Gli1 و Bcl-2 در رده سلولی MKN45 سرطان معده

Background: Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Many traditional treatments for this type of cancer, including chemotherapy and surgery, have significant side effects that limit their effectiveness. Therefore, the development of new therapeutic agents with fewer side effects and higher efficacy is crucial. C-Phycocyanin (C-PC), و...

54- واکسن تراپی هیپرپلازی خوش خیم پروستات (BPH)

هیپرپلازی خوش خیم پروستات (BPH) یکی از شایع ترین بیماری هایی است که مردان مسن را تحت تاثیر قرار می دهد. ایمن سازی فعال در برابر هورمون آزاد کننده گنادوتروپین (GnRH) در دهه 1970 به عنوان وسیله ای بالقوه برای از کار افتادن سیستم تولید مثل پستانداران شناخته شد. از زمان اولین گزارش های ایمن سازی موفقیت آمیز در برابر GnRH، یکی از حوزه های اصلی مورد استفاده، کاربرد ایمونوکستراسیون در و...

55- بررسی سطح سرمی دو آنزیم متابولیک، LDH و FASN, در بیماران مبتلا به سرطان مثانه

Background: Bladder cancer is one of the most common cancers in the world and is associated with high treatment costs and mortality. The role of different enzymes and molecules in this cancer has been the subject of extensive research in recent years. Among these, the role of metabolic enzymes such as FASN and LDH has been studied less than others. Therefore, the present study و...

56- عصاره ریه به عنوان یک عامل محرک برای خون سازی: گسترش کاربرد سلول های بنیادی بند ناف؛ درمان حمایتی لوسمی

Background: Umbilical cord stem cells have numerous therapeutic applications due to their differentiation potential, accessibility, and risk-free procurement. This study utilized the umbilical cord as the primary source of stem cell production, and mouse lung extract, rich in hematopoietic growth factors, was employed to stimulate differentiation into blood cells. Methods: In و...

57- پتانسیل Savolitinib به عنوان مهارکننده ی تیروزین کیناز در سرطان دهانه رحم

Background: Cervical carcinoma is one the most common cancers among women globally. MET, also known as hepatocyte growth factor receptor, is a tyrosine kinase receptor that plays a crucial role in cancer development. Savolitinib is a bioavailable small molecule that acts as a tyrosine kinase inhibitor in a wide range of cancer types. The present study aimed to investigate wheth و...

58- بررسی اثر عصاره ی متانولی آویشن شیرازی (Zataria Multiflora) و ترکیب آن با داروی ATRA بر بیان onco-miRNAs و TS-miRNAs، در رده ی سلولی لوسمی پرومیلوسیتی حاد،(NB4)

Acute promyelocytic leukemia (APL) constitutes 10-15% of adult acute myeloid leukemia cases. Despite significant therapeutic advancementes, particularly through the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), challenges such as APL relapse and the occurence of differentiation syndrome in treated patients continue to impede longe-term success. This study de و...

59- Cancer Therapy by Covalent Organic Framework-Based Sonodynamic Therapy

Despite advances in traditional medicine, cancer remains a global public health issue. Biomaterials play a crucial role in enhancing the effectiveness of cancer immunotherapy and reducing side effects. Nano-biomaterials are promising for targeted cancer therapy but face challenges such as toxicity and reproducibility concerns. Covalent Organic Frameworks (COFs) are new material و...

60- واکسن پیشگیرانه DNA که سلول های T تنظیمی Foxp3+ را هدف قرار می دهد، سلول های سرکوبگر مشتق از میلوئید را کاهش می دهد و پاسخ های ایمنی ضد ملانوم را در مدل موش بهبود می بخشد.

Regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC) are the two important and interactive immunosuppressive components of the tumor microenvironment that hamper anti-tumor immune responses. Therefore, targeting these two populations together might be beneficial for overcoming immune suppression in the tumor microenvironment. We have recently shown that prophyl و...

61- جهش زایی هدفمند در اسید آمینه های Ipilimumab برای بهینه سازی میل ترکیبی آنتی بادی Ipilimumab به آنتی ژن CTLA4 توسط مدل سازی in silico

Abstract Background: Cytotoxic T lymphocyte antigen number 4 (CTLA4) or CD152 is a receptor on the surface of T-cytotoxic cells, which acts as an inhibitor for these cells and causes their inactivation. Since cytotoxic T cells have a very important function in anti-tumor processes, it is important that they remain more active in cancer treatments. Ipilimumab is one of the kno و...

62- بررسی بیان ژن ATG5 و ATG7 مسیراتوفاژی در رده ی سلولی NALM-6 با استفاده از MIR Sponge علیه MIR 17 و MIR181

miRNAs can affect cellular processes by modulating the expression of various genes, thereby playing a vital role in multiple types of cancer. Simultaneously, blocking specific types of miRNAs in all forms of cancer can reduce or stop the activity of cancer cells. Our research has examined how the sponge inhibits these specific miRNAs in NALM-6 cells, which are associated with و...

63- میکروسفرها به عنوان سیستم‌های حامل دارویی در ایمنی‌درمانی سرطان با تمرکز بر درمان تومورهای جامد

Background: Cancer is the leading cause of death globally. While current treatments curb tumor growth, they face challenges. By strengthening the immune system, Immunotherapy shows promise but struggles with solid tumors due to access and diffusion issues. This is where biodegradable and biocompatible microspheres (1 to 1000 µm) come into play, offering controlled drug release و...

64- شناسایی ژن‌های مرکزی کلیدی در سلول‌های بنیادی سرطان کولورکتال به عنوان اهداف درمانی جدید برای غلبه بر مقاومت شیمیایی

Background: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Cancer stem cells (CSCs) are critical in CRC progression, driving tumor initiation, metastasis, and treatment resistance, which often leads to relapse. Targeting CSCs by focusing on central genes in CSCs-related gene networks offers a promising strategy f و...

65- شناسایی و اعتبار سنجی بیومارکر های پتانسیلی تشخیصی در تمایز یافتگی گلایوبلاستوما : ( با رویکرد بیولوژی سیستمی)

Glioblastoma (GBM) continues to be recognized as one of the most aggressive and treatment-resistant malignancies, primarily attributable to the existence of glioblastoma stem-like cells (GSCs). GSCs play a critical role in therapeutic resistance, tumor recurrence, and unfavorable prognoses in the context of glioblastoma. This investigation employed a systems biology framework t و...

66- ارتباط COPD و سرطان ریه؛ ژن های تومورزای مشترک در پاتوژنز این دو بیماری نقش دارند

سرطان ریه در میان شایع ترین علل مرگ و میر در میان سرطان ها قرار دارد، در حالی که بیماری مزمن انسداد ریه (COPD) به عنوان یکی از کشنده ترین اختلالات التهابی موثر بر سیستم ریوی در نظر گرفته می شود. در سال 2019، COPD مسئول حدود 3.23 میلیون مرگ بوده است، در حالی که سرطان ریه در سال 2020 با حدود 1.8 میلیون مرگ علت اصلی مرگ ناشی از سرطان است. مطالعات نشان داده که افراد مبتلا به COPD ب و...

67- تایپ HLA در ایمونوتراپی علیه سلول های بنیادی سرطانی: مروری سیستماتیک بر شواهد فعلی

Human Leukocyte Antigen (HLA) typing is crucial for immune system regulation through specific single nucleotide polymorphisms across multiple exons. Cancer stem cells (CSCs) within the tumor microenvironment pose significant challenges for effectiveness of immunotherapy methods due to various immune evasion mechanisms. This necessitates the development of more targeted treatmen و...

68- آنزیم ماتریکس متالوپروتئیناز 9 به عنوان بیومارکر برای تشخیص کارسینوم سلول سنگفرشی دهان

Negar Jamshidifard ¹ , Zahra Abedian ¹, Niusha abdi ¹ ,safoura jabbari ²* 1-Master of Biochemistry, Department of Biochemistry and Biophysics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Niooooosha.abdi@gmail.com, abedianzahra069@gmail.com 2-Assistant Professor, Department of Biochemistry and Biophysics, Faculty of Advanced Sciences and Technology, Tehran و...

69- القا آپوپتوز توسط سلول های کشنده طبیعی در ترکیب با مهارکننده های تلومراز

Natural Killer Cells in Combination with the Inhibition of Telomerase Induced Apoptosis in Acute Myeloid Leukemia Cells Amirreza Ghamsarian1 , Ali Rafat2,3* , Mohsen Hemmati-Dinarvand4 1 Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. 2 Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, و...

70- Point of care microfluidic systems for targeted breast and ovarian cancer biomarker detection using nanoparticles

Point-of-care (POC) microfluidic systems have emerged as a transformative technology for the rapid and on-site detection of cancer biomarkers, providing an efficient substitute to traditional laboratory-based diagnostics. These systems, which combine the capabilities of microfluidics with the power of nanoparticles, offer several advantages including portability, rapid analysis و...

71- نقش پروتوآنکوژنیک ژن های ARHGAP11A و ARHGAP11B در سرطان تهاجمی مجاری پستان: دو بیومارکر امیدوار کننده برای سرطان پستان

Background: Invasive duct carcinoma (IDC) is one of the most common types of breast cancer (BC) in women worldwide, with a high risk of malignancy, metastasis, recurrence, and death. So far, molecular patterns among IDC cases have not been fully defined. However, extensive evidence has shown that dysregulated Rho family small GTPases (Rho GTPases) including Rho GTPase activatin و...

72- ارزیابی اثر نانوذره بتا-گلوکان پوشش داده شده با دوکسوروبیسین بر سلول های سرطانی کولون

Background: Colorectal cancer (CRC) is known as a significant global health issue, making it crucial to improve diagnostic and treatment methods. Although there have been notable improvements in treatments against cancer, further research is required. In colon cancer, nearly all patients eventually experience drug resistance and stop responding to the approved drugs, making tre و...

73- Liposome-Based Nanoplatforms in Cancer Therapy Using Deep Learning Algorithms

Liposome-based nanoplatforms have emerged as a promising strategy in cancer therapy due to their unique ability to encapsulate therapeutic agents, enhance drug delivery, and reduce systemic toxicity. Recent advancements in nanomedicine have utilized liposomes to improve the pharmacokinetics and bioavailability of anticancer drugs, making them more effective in targeting tumor t و...

74- Artificial Intelligence in Predicting Metastatic Potential in Early-Stage Melanoma Using Gene Expression and Imaging Biomarkers: A Systematic Review

Introduction: Melanoma is one of the most aggressive forms of skin cancer, and its early detection is crucial for improving patient outcomes. Predicting the metastatic potential of melanoma at an early stage is vital for determining appropriate treatment strategies and reducing mortality. Traditional diagnostic methods, including histopathology and imaging, have limitations in و...

75- دیدگاه های ساز و کاری میانکنش Foretinib با MET : بررسی فعالیت ضد سرطانی در ملانوما متاستاتیک

Background: Melanoma is an aggressive skin cancer with increasing incidence rates. In melanoma cells, hepatocyte growth factor (HGF) is continuously produced, activating the c-MET receptor, a tyrosine kinase encoded by the MET proto-oncogene. This activation triggers multiple signaling pathways, including PI3K-AKT, STAT, SRC, and MAPK. Foretinib is an oral multikinase inhibitor و...

76- تهیه نانوساختارهای بلورفوتونی اوپال معکوس: یک بیوسنسور نوری برای تشخیص بیومارکرهای سرطان

Background: Inverse opal (IO) photonic crystals as highly-ordered and well-defined nano-porous structures have the unique optical properties for application in the field of optoelectronics and photonics-based biosensors. Newly, these developed IO arrays have been used as selective and sensitive biosensor for various biomolecules detection like gases, DNA, pathogens, proteins a و...

77- اثرات متادون بر بیان گیرنده شبه تول4 در رده سلولی A549 سرطان ریه سلول غیر کوچک انسان با استفاده از تکنیک‌های In-silico و In vitro چکیده

Objectives: In this study, the effects of methadone and naloxone on the expression of toll‑like receptor 4 (TLR4) gene have been evaluated in human non‑small cell lung carcinoma A549 cell line migration using in‑silico and in vitro techniques. Methods: Lung cancer A549 cell cultures were stimulated for 24 h with methadone (5, 10, and 20 µM) and naloxone (20 and 40 μM) concentr و...

78- In-silico investigation of affinity maturation of Atezolizumab antibody using site-directed mutagenesis

Background: Cancer is considered a serious health challenge, which is the second cause of death in the world. To date, various approaches have been used to suppress tumor cell growth. Recently, cancer immunotherapy has been developed as an effective approach for cancer treatment, in which monoclonal antibodies inhibit immune checkpoints, thereby inhibiting the proliferation of و...

79- دستگاه های قابل بلع برای دارورسانی و نظارت بر سلامت

In the gastrointestinal (GI) tract, ingestible sensors can detect physiological and pathological signals, allowing them to monitor health and diseases like cancer, as well as deliver the therapeutic agents. However, because of poor absorption and rapid enzymatic degradation, many compounds must be injected parenterally to achieve the necessary pharmacokinetics. To address these و...

80- الگوریتم های یادگیری ماشین در پیش بینی نتایج بافت‌سازگاری در پیوند بافت

This study explores the application of machine-learning algorithms to predict histocompatibility outcomes in tissue transplantation. By integrating advanced computational techniques, we aim to enhance the accuracy and reliability of compatibility predictions, thereby improving transplant success rates and patient outcomes. We evaluate various models, including convolutional neu و...

81- آنالیز بیوانفورماتیک سطح بیان ژن BIRC5 در سرطان آدنوکارسینومای معده

Gastric cancer (GC) remains one of the leading causes of cancer mortality worldwide. Gastric carcinogenesis is a multifactorial event arising from deregulated pathways of signaling, mutated genes, and epigenetic aberrations, in combination with the influence of environmental factors. Increasing evidence has demonstrated that tumor progression and invasiveness are accompanied by و...

82- اکنون می توان گفت که گلیوما توسط vorasidenib مهار می شود.

Background: Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer treatments. Gliomas show intratumoural and intertumoural heterogeneity at the histological and molecular levels, and they frequently contain mutations in the isocitrate dehydrogenase 1 (IDH1) or IDH2 gene. IDH-mutant adult-type diffused gliomas are و...

83- Effect of FOXO1 on the Longevity of CAR-T cells

Cancer treatment is still one of the main challenges in medicine. CAR-T cell therapy is the treatment of certain types of cancer and has changed the rest of the procedures. CAR-T cells designed to kill cancer are like bulbs that often burn out due to fatigue and poor endurance. Studies and discoveries have shown that a transcription factor called FOXO1 is responsible for conser و...