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زهرا معین، محبوبه نصیری

The NF-kappa B (NF-κB) signaling pathway can help to explain the link between inflammation and cancer. Tumor necrosis factor-alpha (TNF-α) has been shown to promote tumor initiation, promotion, as well as invasion and metastasis as necessary tissue architecture for tumor development through activation of NF-κB. MiR-146a influences the function of NF-κB and contributes to different aspects of tumorigenesis. In the present study, we evaluated the TNF-α and miR-146a mRNA expression pattern in breast cancer (BC) to shed light on some aspects of breast cancer in the molecular level. Fifty-two women diagnosed with BC (44 DCIS; 8 LCIS) and 52 healthy women as controls were enrolled in the present study. The expression of the TNF-α and miR-146a genes was determined by reverse transcription quantitative-polymerase chain reaction. All cases were examined for the receptor of estrogen and progesterone using Allred scoring and immunohistochemistry for TP53. Hematoxylin-eosin staining was used to differentiate different types of BC. Patient women presented with increased TNF-α and miR-146a expression compared to controls (P < 0.0001). The mRNA expression of miR-146a in women below 50 years was significantly higher than controls, while the expression of TNF-α among women above 50 years was significantly higher compared to controls. Collectively, the data obtained from the present study demonstrated that upregulation of TNF-α and miR-146a expression may involve in tumor initiation and promotion by facilitating malignant cell transformation of breast cells through NF-κB activity.

KEYWORDS: Breast cancer, miR-146a, TNF-α, NF-κB signaling pathway, ductal carcinoma in situ, Lobular carcinoma in situ, gene expression

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معین، زهرا، نصیری، محبوبه، 1404، گفتگوی متقابل بین miR-146a و TNF-α در مسیر سیگنالینگ NF-kB در پاتوژنز سرطان پستان DCIS و LCIS، کنگره بین المللی زیست پزشکی سرطان و سلولهای بنیادی، http://conf.sums.ac.ir/fa/archive_index.php?c=HN-icsbc1&aid=1514226